How retatrutide works for weight loss

Retatrutide is a “triple agonist,” meaning it activates receptors for three different hormones to promote weight loss and improve metabolic health. 

• GLP-1 (glucagon-like peptide-1): Slows down the emptying of the stomach to help you feel fuller for longer.

• GIP (glucose-dependent insulinotropic polypeptide): Supports insulin release after eating and helps the body process fat more efficiently.

• Glucagon: Increases the body’s energy expenditure by encouraging it to burn stored fat. 

Weight loss results from clinical trials

A 48-week phase 2 clinical trial involving adults with obesity demonstrated the following dose-dependent results:

• Average weight loss: At the highest dose (12 mg), participants achieved an average weight loss of 24.2%. Those on the 8 mg dose lost an average of 22.8% of their body weight.

• Significant weight loss achievements: 83% of participants on the 12 mg dose lost 15% or more of their body weight, and 26% lost 30% or more. 

Retatrutide vs. other weight loss drugs

Retatrutide’s triple-action mechanism may give it an edge over existing weight loss medications.